Elagolix

Elagolix is a non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist. It works by suppressing the pituitary secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a reduction in ovarian hormone production. It is primarily used for managing moderate to severe pain associated with endometriosis and uterine fibroids.

Indications

-Moderate to severe pain associated with endometriosis -Management of heavy menstrual bleeding due to uterine fibroids in premenopausal women

Contra-Indications

-Pregnancy (Category X) -Severe hepatic impairment -Known hypersensitivity to Elagolix or its components

Special Precautions

-Monitor for signs of bone loss; supplement with calcium and vitamin D if necessary. -Caution in patients with cardiovascular risk factors due to possible lipid changes. -Not recommended for use in women with osteoporosis.

Side Effects

-Common: Hot flashes, headache, nausea, fatigue, and insomnia -Serious: Bone density reduction, hepatic enzyme elevation, and mood disturbances -Rare: Allergic reactions

Drug Interactions

-Potent CYP3A4 inhibitors or inducers may alter Elagolix plasma concentrations. -Avoid co-administration with drugs highly dependent on CYP3A4 for clearance.