Enclomiphene Citrate
Enclomiphene Citrate is a non-steroidal selective estrogen receptor modulator (SERM) that is primarily used to stimulate endogenous testosterone production by blocking estrogen receptors in the hypothalamus. This action encourages the release of gonadotropins, which, in turn, stimulate the testes to produce testosterone. Enclomiphene is one of the isomers of clomiphene citrate, with the other isomer being zuclomiphene.-Treatment of male hypogonadism -Stimulation of endogenous testosterone production -Off-label use in certain fertility treatments
-The typical dosage for treating hypogonadism ranges from 12.5 mg to 25 mg daily. -Dosage may vary based on the specific condition, patient response, and medical guidance.
-Hypersensitivity to enclomiphene citrate or any of its components. -Patients with liver disease or history of liver dysfunction. -Presence of primary testicular failure. -Pregnant or breastfeeding women (for females using the medication off-label). -Patients with a history of hormone-dependent tumors.
-Regular monitoring of testosterone levels and liver function is recommended during treatment. -Patients with a history of thromboembolic disorders should use enclomiphene citrate with caution. -Use in females, particularly for fertility treatments, is generally off-label and should be supervised by a healthcare provider. -Patients should be aware of the potential for visual disturbances, and those experiencing such symptoms should seek medical advice promptly.
-Common: Headache, nausea, dizziness, fatigue, and visual disturbances. -Rare but serious: Thromboembolic events, liver dysfunction, and significant mood changes.
-Enclomiphene citrate may interact with other hormone-modulating drugs, such as testosterone replacement therapies, anti-estrogens, and some fertility drugs. -Care should be taken when combining enclomiphene with anticoagulants due to the potential risk of increased bleeding.
