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-Enzalutamide is a prescription medication classified as an androgen receptor inhibitor. It is primarily used in the treatment of prostate cancer. Enzalutamide works by blocking the effects of androgens (male hormones) to inhibit the growth and spread of prostate cancer cells. -Enzalutamide is an androgen receptor inhibitor.


Enzalutamide is indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in adult men who have previously received docetaxel chemotherapy and in those who are chemotherapy-naïve. It is indicated for the treatment of patients with: -Castration-resistant prostate cancer (CRPC) -Metastatic castration-sensitive prostate cancer (mCSPC)


-The recommended dose for enzalutamide is typically 160 mg (four 40 mg capsules) administered orally once daily. It is usually taken with or without food. -Oral; 80-160mg once daily


-Enzalutamide is contraindicated in individuals who are hypersensitive to the active substance or any of the excipients. It is also contraindicated in women, especially those who are or may become pregnant, as it may cause harm to a developing fetus. -Hypersensitivity

Special Precautions

-Special precautions should be taken in patients with a history of seizures, as enzalutamide has been associated with an increased risk of seizures. Regular monitoring of liver function is recommended, and dose adjustments may be necessary in patients with hepatic impairment. Paediatric: Safety and efficacy in pediatric patients have not been established Pregnancy: Data not sufficient Lactation: Data not sufficient Elderly: No overall differences in safety or effectiveness have been observed between elderly and other adult patients.

Side Effects

-Common side effects of enzalutamide include fatigue, back pain, hot flashes, hypertension, and diarrhea. Serious side effects may include seizures, falls, and fractures. Patients should promptly report any unusual symptoms or side effects to their healthcare provider. -Seizure, Posterior Reversible Encephalopathy Syndrome (PRES), Ischemic Heart Disease , Falls and Fractures, Hypersensitivity, asthenia/fatigue, back pain, hot flush, constipation, arthralgia, decreased appetite, diarrhea, and hypertension.

Drug Interactions

-Enzalutamide may interact with drugs that are substrates, inducers, or inhibitors of cytochrome P450 enzymes. It is important to inform healthcare providers about all medications, including over-the-counter drugs and herbal supplements, being taken to avoid potential interactions. -Carbamazepine, phenytoin, cyclosporine

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