Ephedrine
Primarily acts indirectly but has some direct action on a and b receptors also. It is about 100 times less potent than adrenaline but longer acting (4-6 hrs.). Used as nasal decongestant due to its vasoconstrictive action.Nasal congestion.
3 drops in each nostril 2-3 times daily.
Debilitated patients or those with impaired cough reflex. Infants.
Prolonged use may cause rebound congestion. Cardiac disease.
Anxiety/restlessness, insomnia, confusion, tremor, urinary difficulties, palpitations/chest pain.
Severe hypertension in combination with MAOI ‘s. Reduce antihypertensive effect of bethanidine, guanethidine. Alcohol and Phenobarb antagonise CNS stimulant effect of Ephedrine. Synergistic bronchlator effect but increased incidence of adverse effects with theophylline.
