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Esomeprazole with Naproxen

Esomeprazole with Naproxen

Esomeprazole with Naproxen is a combination medication that includes esomeprazole, a proton pump inhibitor (PPI), and naproxen, a nonsteroidal anti-inflammatory drug (NSAID). Esomeprazole reduces stomach acid production, while naproxen helps to relieve pain and inflammation.


This combination is indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in patients at risk of developing NSAID-associated gastric ulcers.


Dosage should be individualized based on patient needs. Typically, one tablet is taken twice daily, with or without food. It is important to follow the prescribed dosage and administration guidelines.


This medication is contraindicated in patients with a history of hypersensitivity to esomeprazole, naproxen, or any other components of the formulation. Contraindications also include active gastrointestinal bleeding, severe renal impairment, and advanced liver disease.

Special Precautions

Special precautions should be taken in patients with a history of cardiovascular events, hypertension, heart failure, or edema. Careful monitoring is essential in those with impaired renal function, as well as in elderly patients. The risk of gastrointestinal bleeding, ulceration, and perforation is increased with NSAID use, particularly in older adults.

Side Effects

Common side effects may include nausea, headache, indigestion, and gastrointestinal discomfort. Serious side effects include gastrointestinal bleeding, cardiovascular events, and renal impairment. Immediate medical attention is required if symptoms such as chest pain, shortness of breath, or signs of bleeding occur.

Drug Interactions

Esomeprazole with Naproxen may interact with anticoagulants, antiplatelet agents, corticosteroids, selective serotonin reuptake inhibitors (SSRIs), and certain antifungal medications. Consultation with a healthcare professional is advised before starting or discontinuing any medications.

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