Estradiol

Estradiol is a form of estrogen, a female sex hormone. It is used to replace estrogen in women who are going through menopause, have had their ovaries removed, or have conditions that cause low estrogen levels. It may also be used in other circumstances as determined by a healthcare provider. Estradiol helps maintain bone density, reduces menopausal symptoms, and supports overall female health.

Indications

-Menopausal symptoms (e.g., hot flashes, vaginal dryness) -Prevention of osteoporosis in postmenopausal women -Hypoestrogenism due to ovarian failure or other conditions -Palliative treatment of certain cancers (e.g., prostate, breast)

Dosage

-The dosage and duration of treatment vary depending on the condition being treated and the form of estradiol (e.g., tablets, patches, gels, injections). -Typically, the lowest effective dose is prescribed for the shortest duration needed. -Follow your healthcare provider's instructions for dosage and administration.

Contra-Indications

-Known or suspected breast cancer or other estrogen-dependent tumors -Undiagnosed abnormal vaginal bleeding -Active or recent history of arterial thromboembolic disease (e.g., stroke, heart attack) -Liver dysfunction or disease -Known hypersensitivity to estradiol

Special Precautions

-Regular monitoring is required, including mammograms and pelvic exams. Use caution in patients with a history of blood clots, heart disease, or liver disease. -May increase the risk of endometrial cancer; combined use with a progestin is recommended for women with an intact uterus. -Use caution in patients with a history of depression or migraines.

Side Effects

-May interact with medications such as anticoagulants, thyroid hormones, and certain antibiotics or antifungal medications. -Grapefruit juice may increase the concentration of estradiol in the blood. -Consult with a healthcare provider for a full list of potential interactions.