Estrogen deficiency due to the menopause. Prevention of accelerated postmenopausal bone loss.
Application once every 3-4 days. Continuous or cyclic administration.
Carcinoma of the breast or endometrium;endometriosis, vaginal bleeding of unknown origin; severe liver damage; a history of, or active thrombophlebitis, thrombosis, or thromboembolic disorders;, hypersensitivity, pregnancy and lactation.
Heart failure, hypertension, disorders of renal or hepatic function, epilepsy, migraine, fibrocystic disease of the breasts, leiomyomas of the uterus, diabetes, family history of breast cancer.
Skin irritation, breast discomfort, migraine, generalised pruritus and exanthema. thrombophlebitis.