Eszopiclone

An S-enantiomer of Zopiclone - a nonbenzodiazepine hypnotic of cyclopyrrolone, with repaid onset of action.

Indications

Short-term treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

Dosage

Administered orally before bedtime. Adult: 2-3 mg, Elderly: 1-2 mg, Hepatic impairment : 1mg, Debilitated patients : 1mg concurrent use with strong CYP3A4 inhibitors : 1-2mg.

Contra-Indications

-Hypersensitivity to eszopiclone or any component of the formulation. -History of complex sleep behaviors such as sleep-walking, sleep-driving, or other activities while not fully awake.

Special Precautions

Children below 18 year of age, pregnancy, lactation, history of drug or alcohol dependent and/or abuse, do not drive and operate machinery, abrupt discontinuance may cause withdrawal symptoms.

Side Effects

Dry mouth, unpleasant taste, nausea, vomiting, diarrhea, dyspepsia, headache, dizziness, somnolence, nervousness, anxiety, abnormal dream, memory impairment, dysphonia, decreased libido, migraine, neuralgia, peripheral edema, rash, pruritus, dysmenorrhea, gynecomastia, chest pain, urinary tract infection, viral infection.

Drug Interactions

Concurrent use with CYP3A4 inhibitors increase plasma concentration of eszopiclone while CYP3A4 inducers reduce plasma concentration, when used with alcohol, anticoagulants, antihistamines or other Psychotropic drugs, it may enhance CNS effects. With Flumazenil may diminish sedative effect.