FLUMAZENIL

Indications

Antidote for benzodiazepine overdose, reversal of sedative effects produced by benzadiazepenes administered during general anaesthesia or diagnostic or therapeutic procedures.

Dosage

Adult : 0.2 mg (2ml) administered over 30 seconds, i.v., repeat 0.3 mg and 0.5 mg at 1 to 2 min intervals, Not more than 3 mg over one hour. Child : 10ug.kg, i.v. for 2 dose

Contra-Indications

Epilepsy, neuromuscular blockade, hypersensitivity to benzodiazepines, patients of suspected tricyclic antidepressant overdose, raised intracranial pressure.

Special Precautions

History of seizures, panic attack, alcohol drug dependence, bleeding, disorder, liver disease, head injury, respiratory depression, pregnancy.

Side Effects

Convulsions, fatigue, injection site pains, increased seeating, facial erythema, raised intracranial pressure, agitation, dizziness, abnormal vision, may cause complete heart block, flushing, transient increase in blood pressure and heart rate.