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Fluoxetine Hydrochloride- Drug Interactions, Dosage, Side Effects, indications, Uses and Precautions

Look for Drugs and Conditions

FLUOXETINE HYDROCHLORIDE

FLUOXETINE HYDROCHLORIDE

It is potent antidepressant with non-sedating properties. The anti-depressant action of fluoxetine is presumed to be linked to its inhibition of C.N.S. neuronal uptake of serotonin. Fluoxetine has negligible binding to muscarinic, histaminergic and alpha1-adrenergic receptors in comparision to ticyclic agents.

Indications

All types of depression, especially where no sedation is required.


Dosage

Initially 20 mg once a day in the morning followed by range of 20-80 mg per day, after several weeks if there is no therapeutic response.


Contra-Indications

Hypersensitivity. Severe renal failure, nursing mothers.


Special Precautions

At least 14 days gap between discontinuation of MAO inhibitor & initiation of Fluoxetine. Pregnancy, lactation, possibility of suicide attempt, mania, hypomania or convulsions. Epileps, renal, hepatic or cardiac disease. Weight loss, driving, operating machinery. Paediatrics: Not recommended. Pregnancy: Safety not established. Lactation: The drug passes into breast milk and may affect the infant. Elderly: Reduced dose necessary.


Side Effects

Anxiety, nervousness, insomnia, drowsiness, fatigue or lethargy; tremor, sweating. G.I. complaints like anorexia, nausea, diarrhoea, light headedness


Drug Interactions

Tryptophan may produce agitation, restlessness and gastric distress. Increased sedative effects on the CNS. Fluoxetinereduces the breakdown of tricyclic antidpressants, change in serum lithium level.


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