Flupirtine maleate

Flupirtine Maleate is a nonopioid centrally-acting analgesic agent with muscle relaxant and neuro protective properties. It appears to work by suppressing pain perception transmission to the brain and spinal cord through stimulation of descending monoaminergic pathways. The drug appears to work by affecting noradrenaline. Flupirtine does not reduce inflammation or fever. The drug works best for pain associated with noninflammatory conditions. In addition to alleviating pain, Flupirtine relaxes muscles through GABA-ergic mechanisms.

Indications

Acute or chronic pain

Dosage

Oral; 100-600 mg 3 or 4 daily divided doses

Contra-Indications

Hypersensitivity, myasthenia gravis, hepatic enchephelopathy.

Special Precautions

Elderly : Start with lower dose due to reduced renal clearance in elders

Side Effects

Sedation, dizziness, dry mouth, nausea, headache, heart burn sweating, vomiting.

Drug Interactions

Warfarin, may alter PT. Benzodiazapine, alcohol and sedatives may increase sedation.