FLUTICASONE FUROATE

Fluticasone furoate is a synthetic corticosteroid with potent anti-inflammatory properties. It is primarily used to manage symptoms of various respiratory conditions, including asthma and allergic rhinitis. Available in nasal spray, inhaler, and topical cream forms, fluticasone furoate works by reducing inflammation in the airways and nasal passages, providing relief from symptoms such as congestion, sneezing, and itchy, watery eyes.

Indications

-Fluticasone furoate is indicated for: -Asthma: As maintenance treatment for the management of persistent asthma in adults and children. -Allergic rhinitis: For the relief of nasal symptoms such as congestion, sneezing, and runny nose in adults and children. -Atopic dermatitis: As a topical cream for reducing inflammation and itching.

Dosage

-Nasal Spray: Usually, one or two sprays per nostril once daily. -Inhaler: The dosage varies; typically, it is administered once or twice daily, depending on the severity of asthma. -Topical Cream: Apply a thin layer to the affected area once daily.

Contra-Indications

Have known hypersensitivity or allergy to fluticasone furoate or any of its ingredients.

Special Precautions

-Long-term use: Prolonged use may lead to systemic side effects such as adrenal suppression and growth retardation in children. -Infections: Caution should be exercised in patients with active or quiescent tuberculosis or untreated infections. -Eye Health: Monitor for increased intraocular pressure, glaucoma, or cataracts. -Pediatrics: Use with caution in children, as it may impact growth. -Pregnancy and lactation: Use only if clearly needed and after consulting a healthcare provider

Side Effects

-Nasal irritation, sore throat, and epistaxis (nosebleed) for the nasal spray form. -Hoarseness and coughing for the inhaler form. -Localized skin irritation and itching for the topical cream form.

Drug Interactions

-CYP3A4 inhibitors: Concurrent use with potent CYP3A4 inhibitors (e.g., ritonavir) may increase systemic exposure to fluticasone furoate, potentially leading to side effects. -Other corticosteroids: Concurrent use may increase the risk of systemic corticosteroid effects.