Fluvastatin

Fluvastatin is a medication belonging to the class of statins, which are used to lower cholesterol levels in the blood. It works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in the production of cholesterol in the liver.

Indications

-As an adjunct to diet to reduce elevated total cholesterol (Total-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and apolipoprotein B (Apo B) levels, and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Type IIa and IIb). • as an adjunct to diet to reduce Total-C, LDL-C, and Apo B levels in adolescent boys and adolescent girls who are at least one year post-menarche, 10-16 years of age, with heterozygous familial hypercholesterolemia and the following findings are present: LDL-C remains 190 mg/dL or LDL-C remains , 160 mg/dL and: there is a positive family history of premature cardiovascular disease or two or more other cardiovascular disease risk factors are present Secondary Prevention of Cardiovascular Disease In patients with clinically evident CHD to: • reduce the risk of undergoing coronary revascularization procedures • slow the progression of coronary atherosclerosis -Fluvastatin is primarily prescribed to treat high cholesterol levels and reduce the risk of cardiovascular events such as heart attacks and strokes. It is often part of a comprehensive approach to managing cardiovascular health, including lifestyle changes such as diet and exercise.

Dosage

-The dosage of fluvastatin can vary based on individual patient factors and the specific product prescribed. It is typically taken orally, with or without food. The prescribing healthcare professional will determine the appropriate dosage for each patient. -Oral; 20 mg to 80 mg/ day.

Contra-Indications

-Fluvastatin is contraindicated in individuals with a known hypersensitivity to the drug. It should not be used in patients with active liver disease or unexplained persistent elevations in liver function tests. -Hypersensitivity to component of medicine

Special Precautions

-Caution is advised in patients with a history of liver disease. -Pregnant and breastfeeding women should consult their healthcare provider before using fluvastatin. -Routine monitoring of liver function may be necessary during treatment. Paediatric: Use with caution; safety and efficacy studied in 9 to 16 year age group Pregnancy: Not to use; category X Lactation: Not to use Elderly: Use with caution.

Side Effects

-Common side effects may include headache, muscle pain, gastrointestinal disturbances, and rash. Serious but rare side effects include liver problems and muscle breakdown (rhabdomyolysis). Patients experiencing unexplained muscle pain or weakness should seek medical attention promptly. -Abdominal pain, diarrhea, nausea, dyspepsia and chest pain, Rhabdomyolysis with myoglobinuria and acute renal failure and myopathy (including myositis), Liver Enzyme Abnormalities

Drug Interactions

-Fluvastatin may interact with other medications, including: Cyclosporine Warfarin Gemfibrozil Certain antifungal medications Patients should inform their healthcare provider about all medications, including over-the-counter drugs and supplements, before starting fluvastatin. -Fluconazole, cyclosporin, gemfibrozil, niacin, glyburide, phenytoin, warfarin, colchicine