Fluvoxamine
-Fluvoxamine is an antidepressant medication that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It is primarily used to treat mood and anxiety disorders by increasing the levels of serotonin in the brain, which helps regulate mood and anxiety. -It is a selective serotonin (5-HT) receptor inhibitor (SSRI). It is chemically unrelated to other SSRIs and clomipramine.-Major Depressive Disorder: Fluvoxamine can be prescribed to manage symptoms of major depressive disorder. -Obsessive-Compulsive Disorder (OCD): It is commonly used to treat OCD in adults and children over eight years old. -Anxiety Disorders: Fluvoxamine may be used to treat social anxiety disorder and other anxiety-related conditions.
Adults: The recommended starting dose of fluvoxamine in adult patients is 50mg/day, administered as a single dose at bedtime. The effective dose range is 100 to 300mg/day. The dosage may be increased in 50mg increments every 4 to 7 days, until maximum therapeutic benefit is achieved or a maximum dosage of 300mg/day is reached. It is advisable that if daily dose is more than 100mg, it should be given in two divided doses; if the two doses are not equal, the larger doses should be given at bedtime
Coadministration of terfenadine, astemizole, or cisapride with Fluvoxamine is contraindicated. Patients with history of hypersensitivity to fluvoxamine maleate.
-Suicidal Thoughts and Behaviors: Monitor patients, especially young adults and children, for suicidal thoughts or behavior changes. -Serotonin Syndrome: Watch for symptoms such as agitation, hallucinations, or rapid heart rate, as fluvoxamine can increase the risk when combined with other drugs affecting serotonin. -Bleeding Risk: Caution is needed when combined with other drugs that increase bleeding risk, such as NSAIDs. -Seizure Risk: Use fluvoxamine with caution in patients with a history of seizures.
Headache , asthenia, flu like syndrome, and chills. Nausea, vomiting, flatulence, diarrhea, constipation, dyspepsia, agitation, decreased libido,anorexia, tooth disorder, dysphagia. Somnolence, dizziness, insomnia, dry mouth, nervousness, tremor, anxiety, vasodilatation, hypertonia, depression, CNS stimulation, Upper respiratory infection, Dyspnoea, amblopia. Abnormal ejaculation, yawn. Sweating. Taste preversion, impotence, anorgasmia, urinary frequency, urinary retention.
Drugs that are metabolized by and/or inhibit cytochrome P450 isoenzymes: A clinically significant fluvoxamine interaction is possible with drugs having a narrow therapeutic ration such as terfenadine, astemizole, cisapride, warfarin, theophylline, certain benzodiazepines and phenytoin.
