Glibenclamide with Metformin

Glibenclamide with Metformin is a combination medication used to treat type 2 diabetes mellitus. It works by lowering blood sugar levels through different mechanisms: Glibenclamide stimulates insulin release from the pancreas, while Metformin improves insulin sensitivity and reduces glucose production in the liver.

Indications

Treatment of type 2 diabetes mellitus when diet, exercise, and single-agent therapy with either Glibenclamide or Metformin do not achieve adequate glycemic control.

Dosage

The dosage should be individualized based on the patient's current regimen. Typical starting doses may include Glibenclamide 2.5 mg to 10 mg once daily and Metformin 500 mg to 2000 mg daily in divided doses.

Contra-Indications

Hypersensitivity to Glibenclamide, Metformin, or any component of the formulation; diabetic ketoacidosis, severe renal impairment (eGFR <30 mL/min/1.73 m²), metabolic acidosis.

Special Precautions

Monitor renal function regularly; discontinue use if lactic acidosis is suspected; caution in elderly patients and those with hepatic impairment.

Side Effects

ommon side effects may include hypoglycemia, gastrointestinal disturbances (nausea, vomiting, diarrhea), headache, dizziness, and skin reactions.

Drug Interactions

Potential interactions with other medications, including certain antibiotics, antifungals, and beta-blockers. Consult prescribing information for specific drug interactions.