INDOMETHACIN

It is a potent anti-inflammatory & promptly acting antipyretic but it relieves only inflammatory or tissue injury related pain.

Indications

Rheumatoid arthritis not controlled by aspirin, ankylosing spondylitis, destructive arthropathias and psoriatic arthiritis, acute gout. Bartte’s syndrome.

Dosage

Adults: 25-50 mg 2-4 times daily. Neonates: 0.2 mg/kg/dose for 3 doses 12 hourly.

Contra-Indications

Machinery operators, drivers, psychiatric patients, epileptics, kidney disease. Hypersensitivity.

Special Precautions

Active peptic ulcer, Renal or hepatic dysfunction. Paediatrics: Usually not prescribed for children under 14 except for patent ductus arteriosus in neonates. Pregnancy: Not prescribed. Lactation: Unsafe. Elderly: Reduced dose is necessary.

Side Effects

Gastric irritation, nausea, anorexia, gastric bleeding, diarrhoea, frontal headache, dizziness, mental confusion, hallucination, depression, psychosis, can induce asthma.

Drug Interactions

With salicylates, lithium, anticoagulants, corticosteroids, diuretics, b-blockers, probenecid.