Irbesartan with S(-)Amlodipine

Irbesartan with S(-)Amlodipine is a combination medication that contains two active ingredients: irbesartan and S(-)amlodipine. Irbesartan is an angiotensin II receptor blocker (ARB), while S(-)amlodipine is a calcium channel blocker. This combination is used to treat hypertension (high blood pressure) by addressing different mechanisms that contribute to elevated blood pressure.

Indications

This medication is indicated for the management of hypertension (high blood pressure) in adults when control of blood pressure is not achieved with monotherapy.

Dosage

The dosage of Irbesartan with S(-)Amlodipine should be individualized based on the patient's response and tolerance. Typically, the starting dose is determined by the individual doses of each component. It is crucial to follow the prescribed dosage regimen provided by the healthcare provider.

Contra-Indications

Irbesartan with S(-)Amlodipine is contraindicated in patients with known hypersensitivity to any of its components, in pregnant women, and in patients with severe hepatic impairment.

Special Precautions

-Caution should be exercised in patients with renal impairment. -Hypotension may occur, especially in patients with volume depletion. -Regular monitoring of blood pressure and renal function is recommended. -Use with caution in elderly patients.

Side Effects

Common side effects may include dizziness, edema, flushing, headache, and fatigue. Serious but rare side effects may include hypotension, hyperkalemia, and renal dysfunction.

Drug Interactions

-Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase the risk of hyperkalemia. -CYP3A4 inhibitors or inducers may affect the metabolism of amlodipine.