ISOFLURANE

Isoflurane is a volatile anesthetic agent used for inducing and maintaining general anesthesia during surgery. It is known for its rapid onset and recovery times.

Indications

Induction and maintenance of general anesthesia in surgical procedures.

Dosage

Adult: Inhalation Induction: Initial: 0.5% v/v w/ oxygen or oxygen and nitrous oxide, increase to 1.5-3% v/v. Maintenance: 1-2.5% v/v w/ oxygen and nitrous oxide mixtures or 1.5-3.5% v/v w/ oxygen only. For maintenance of anesth during caesarean section: 0.5-0.75% v/v w/ oxygen and nitrous oxide mixtures.

Contra-Indications

-Known hypersensitivity to Isoflurane or other halogenated anesthetics. -Patients with a history of malignant hyperthermia. -Certain heart conditions (e.g., severe coronary artery disease) may be exacerbated.

Special Precautions

Perioperative hyperkalaemia; raised intracranial pressure. May impair ability to drive or operate machinery.

Side Effects

-Respiratory depression. -Hypotension. -Nausea and vomiting. -Possible liver toxicity with prolonged use.

Drug Interactions

-May interact with other anesthetic agents, sedatives, and muscle relaxants. -Can potentiate the effects of neuromuscular blockers.