Isoxsuprine Hydrochloride

Isoxsuprine Hydrochloride is a vasodilator medication primarily used to treat peripheral vascular diseases. It works by relaxing blood vessels, improving blood flow to various parts of the body, and is also utilized in managing certain conditions in pregnancy to prevent premature labor.

Indications

-Peripheral vascular diseases such as arteriosclerosis, Buerger's disease, and Raynaud's disease. -Management of symptoms associated with cerebrovascular insufficiency. -In obstetrics, it is sometimes used off-label to manage premature labor.

Dosage

-The typical adult dose for peripheral vascular disease ranges from 10 to 20 mg taken orally three or four times daily. -For obstetric use, dosage and administration should be determined by a healthcare provider, typically involving controlled intravenous administration in a hospital setting.

Contra-Indications

-Hypersensitivity to Isoxsuprine or any of its components. -Recent arterial bleeding or recent childbirth. -Severe hypotension. -Use in patients with a history of bleeding disorders should be avoided.

Special Precautions

-Caution in patients with cardiovascular diseases, particularly those with arrhythmias or severe coronary artery disease. -Should be used cautiously in patients with a history of peptic ulcer or those prone to gastrointestinal bleeding. -Regular monitoring of blood pressure and heart rate is recommended during treatment. -The safety of Isoxsuprine in pregnant women for uses other than the approved indications is not well-established.

Side Effects

-Common side effects include dizziness, flushing, gastrointestinal disturbances (nausea, vomiting), and headache. -Hypotension and tachycardia can occur, especially with higher doses or in sensitive individuals. -Rarely, allergic reactions such as rash, itching, or severe dizziness may occur.

Drug Interactions

-Concurrent use with antihypertensive drugs may potentiate the hypotensive effects. -Caution with other vasodilators or medications affecting cardiovascular function. -Interactions with beta-blockers and digitalis have been noted; consult a healthcare provider for a comprehensive list.