Itraconazole with Ornidazole

Itraconazole is an antifungal medication that belongs to the triazole class. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. Ornidazole is an antimicrobial agent with activity against anaerobic bacteria and some protozoa. The combination of Itraconazole with Ornidazole is used for specific infections that may involve both fungi and bacteria/protozoa.

Indications

-Fungal infections resistant to single-agent therapy. -Mixed infections involving both fungi and susceptible bacteria/protozoa.

Dosage

Dosage may vary based on the specific condition and patient characteristics. A healthcare professional should be consulted for precise dosage recommendations.

Contra-Indications

-Hypersensitivity to Itraconazole or Ornidazole. -Use of certain medications that interact adversely with Itraconazole (e.g., Cisapride, Pimozide). -Severe hepatic dysfunction.

Special Precautions

-Caution in patients with liver or kidney impairment. -Monitoring for potential drug interactions. -Avoiding alcohol during treatment. -Pregnancy and lactation - use only if benefits outweigh risks.

Side Effects

-Gastrointestinal disturbances (nausea, vomiting, diarrhea). -Headache. -Rash. -Elevated liver enzymes. -Neurological symptoms (rare).

Drug Interactions

-Concomitant use of drugs metabolized by CYP3A4. -Potential interactions with other antifungal agents. -Caution with drugs that may prolong QT interval (e.g., certain antibiotics, antipsychotics).