L-Asparaginase

Observing the qualitative difference observed between normal cells and those from childhood lymphoblastic leukemia - the leukemia cells are deficient in L-aspargine synthetase and depend on the supply of L-asparagine from the medium. The enzyme L-asparaginase (from E. coli) degrades L-asparagine to L-aspartic acid, depriving leukemic cells of an essential metabolite - may cause cell death.

Indications

Acute leukaemia. Malignant lymphoma..

Dosage

50-200 k.u/kg body wt. daily or every alternate day by i.v infusion.

Contra-Indications

Hypersensitivity.

Special Precautions

Anaphylaxis can occur, allergic reaction (being a foreign protein). Paediatrics: Safe. Pregnancy: Should not be used. Lactation: Should not be used. Elderly: Use with caution.

Side Effects

Liver damage, pancreatitis & C.N.S symptoms (due to defective protein synthesis)

Drug Interactions

Vincristine and prednisolone increases the toxicity, diminishes or abolishes the effect of methotrexate on malignant cells.