Observing the qualitative difference observed between normal cells and those from childhood lymphoblastic leukemia - the leukemia cells are deficient in L-aspargine synthetase and depend on the supply of L-asparagine from the medium. The enzyme L-asparaginase (from E. coli) degrades L-asparagine to L-aspartic acid, depriving leukemic cells of an essential metabolite - may cause cell death.
Acute leukaemia. Malignant lymphoma..
50-200 k.u/kg body wt. daily or every alternate day by i.v infusion.
Anaphylaxis can occur, allergic reaction (being a foreign protein).
Pregnancy: Should not be used.
Lactation: Should not be used.
Elderly: Use with caution.
Liver damage, pancreatitis & C.N.S symptoms (due to defective protein synthesis)
Vincristine and prednisolone increases the toxicity, diminishes or abolishes the effect of methotrexate on malignant cells.
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