L-Carnitine

L-Carnitine is a naturally occurring amino acid derivative that plays a crucial role in the production of energy. It is involved in the transportation of long-chain fatty acids into the mitochondria, where they are burned for energy. L-Carnitine is found in most cells of the body, particularly in skeletal muscles, heart, and brain. It is available as a dietary supplement and is often used for various health benefits.

Indications

Primary Carnitine Deficiency: L-Carnitine is indicated for the treatment of primary carnitine deficiency. Secondary Carnitine Deficiency: It can be used to treat carnitine deficiency associated with other medical conditions such as chronic kidney disease and certain metabolic disorders.

Dosage

Primary and Secondary Carnitine Deficiency: Typically, adults may be prescribed doses ranging from 990 mg to 3,990 mg per day, split into smaller doses. Supplemental Use: Doses of 500 mg to 2,000 mg per day are commonly used in supplementation for athletic performance or weight loss.

Contra-Indications

Allergy: L-Carnitine should not be used in individuals who have a known allergy to L-Carnitine or any of its ingredients. Renal Dysfunction: Individuals with severe renal impairment may require dose adjustment or should avoid use altogether.

Special Precautions

Pregnancy and Lactation: Consult a healthcare professional before using L-Carnitine during pregnancy or breastfeeding. Seizure Disorders: L-Carnitine may increase the risk of seizures in people with a history of seizures, particularly in those with underlying conditions such as epilepsy.

Side Effects

Gastrointestinal issues such as nausea, vomiting, diarrhea, and abdominal cramps. A fishy body odor due to the metabolism of L-Carnitine.

Drug Interactions

Valproic Acid: L-Carnitine may interact with valproic acid, a medication used to treat epilepsy and bipolar disorder. This can increase the risk of side effects associated with valproic acid. Thyroid Hormone: L-Carnitine may interfere with thyroid hormone levels, so individuals on thyroid medication should monitor their levels closely.