LAMIVUDINE WITH STAVUDINE AND NEVIRAPINE

Lamivudine, Stavudine, and Nevirapine are antiretroviral medications used in the management of HIV (Human Immunodeficiency Virus) infection. -Lamivudine: It belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and inhibits the reverse transcriptase enzyme, crucial for HIV replication. -Stavudine: Also an NRTI, it interferes with viral RNA-dependent DNA polymerase, impeding the replication of HIV. -Nevirapine: Classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI), it acts by binding to and inhibiting the reverse transcriptase enzyme.

Indications

This combination is typically prescribed for the treatment of HIV infection in adults and children, helping to control the virus and improve the immune system.

Dosage

Dosage may vary based on individual patient factors. Consult a healthcare professional for the appropriate regimen.

Contra-Indications

-Hypersensitivity to any of the components. -Severe hepatic impairment.

Special Precautions

-Regular monitoring of liver function. -Not recommended during pregnancy or breastfeeding without proper medical evaluation.

Side Effects

-Common side effects may include nausea, headache, fatigue. -Serious side effects can include liver toxicity, lactic acidosis, and skin reactions.

Drug Interactions

-Concomitant use with drugs that affect liver function may increase the risk of hepatotoxicity. -Stavudine may interact with drugs affecting mitochondrial function.