LEUCOVORINFolinic acid (Leucovorin) is an active coenzyme form and does not need to be reduced by DHF Rase before it can act. Methotrexate is a DHF Rase inhibitor; its toxicity is not counteracted by folic acid but antagonised by folinic acid.
Antidote for methotrexate & folic acid antagonists.
Dose equal to antagonist given: to be given within 1 hr. Usually ineffective if given after 3 hrs.
ernicious anaemia and megaloblastic anaemia secondary to the lack of vit B12.
Undiagnosed megaloblastic anaemia, folate dependent tumors. Paediatrics: Use with caution. Pregnancy: Safety not established. Lactation: Saferty not established. Elderly: May cause severe G.I. disturbances and other adverse effects.
Allergic sensitization, nausea, pyrexia, vomiting, urticaria, anaphylactic reactions.
Enhances cytotoxic effect of fluorouracil. Reduces methotrexate toxicity. Phenobarbitone, phenytoin, primidone counteracts the antiepileptic effects.
|Brand Name||Manufactured by|
|CALCILUC||AAA PHARMACEUTICALS PVT. LTD.|
|CEVORIC-C||HEALTH BIOTECH LTD.|
|LEUCATAX||TAXANE HEALTHCARE PVT. LTD.|
|RECOVORIN||CADILA PHARMACEUTICALS LTD.|
|ZOVORIN||ZUVIUS LIFE SCIENCES|