Levofloxacin with Azithromycin

Levofloxacin and Azithromycin are both antibiotics used to treat bacterial infections. Levofloxacin belongs to the fluoroquinolone class, while Azithromycin is a macrolide antibiotic.

Indications

This combination is prescribed for the treatment of various respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted diseases caused by susceptible bacteria.

Dosage

The dosage may vary depending on the specific infection and patient's condition. It is crucial to follow the healthcare provider's prescription. Typically, the dosages are adjusted based on the severity of the infection.

Contra-Indications

This combination is contraindicated in patients with a history of hypersensitivity to levofloxacin, azithromycin, or any other quinolones/macrolides. It should also be avoided in patients with a history of tendon disorders related to fluoroquinolone use.

Special Precautions

-Caution is advised in patients with a history of liver or kidney disorders. -Patients should be monitored for signs of tendonitis or tendon rupture during treatment. -This combination may cause photosensitivity; patients should avoid excessive sunlight exposure. -Use with caution in elderly patients as they may be more susceptible to side effects.

Side Effects

Common side effects may include nausea, diarrhea, headache, and dizziness. Serious side effects include tendon rupture, Clostridium difficile-associated diarrhea, and QT prolongation. If any unusual or severe symptoms occur, medical attention should be sought.

Drug Interactions

-Concurrent use with other drugs that prolong the QT interval may increase the risk of cardiac arrhythmias. -Antacids containing aluminum or magnesium may reduce the absorption of levofloxacin. -Avoid combining with drugs that can cause tendon disorders, such as corticosteroids.