Lisdexamfetamine
Lisdexamfetamine is a central nervous system (CNS) stimulant prodrug of dextroamphetamine. It is used primarily to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder (BED). It works by increasing the levels of certain neurotransmitters in the brain, thereby improving attention, focus, and impulse control.-Attention Deficit Hyperactivity Disorder (ADHD) -Binge Eating Disorder (BED) in adults
-ADHD: Starting dose: 30 mg once daily in the morning. Dose may be increased by 10-20 mg at weekly intervals. Maximum dose: 70 mg per day. -BED: Starting dose: 30 mg once daily in the morning. Dose may be increased by 20 mg at weekly intervals. Maximum dose: 70 mg per day.
-Hypersensitivity to lisdexamfetamine or amphetamines. -Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days. -Symptomatic cardiovascular disease or advanced arteriosclerosis. -Moderate to severe hypertension. -Hyperthyroidism. -Glaucoma. -Agitated states. -History of drug abuse.
-Monitor for potential cardiovascular issues, such as blood pressure and heart rate. -Risk of peripheral vasculopathy, including Raynaud's phenomenon. -Potential for abuse and dependence; assess risk before prescribing. -Use with caution in patients with a history of psychiatric disorders, including bipolar disorder and psychosis. -Long-term growth monitoring in children. -Potential for serotonin syndrome, particularly when used with other serotonergic drugs.
-Decreased appetite -Insomnia -Dry mouth -Increased heart rate -Anxiety -Irritability -Weight loss -Dizziness -Nausea -Diarrhea -Upper abdominal pain
-MAOIs: Increased risk of hypertensive crisis. -SSRIs, SNRIs, and other serotonergic drugs: Increased risk of serotonin syndrome. -Antihypertensive medications: Possible reduction in the efficacy of antihypertensive drugs. -Acidifying and alkalinizing agents: May affect the excretion of amphetamines. -Tricyclic antidepressants: Increased risk of cardiovascular side effects.
