Lomustine (Nitrosoureas)

It is highly lipid soluble alkylating agent with a wide range of antitumour activity. They cross blood brain barrier and are effective in meningeal leukemias & brain tumours.

Indications

Meninigeal leukemias, brain tumours, Hodgkin's disease.

Dosage

100-130mg/sqm body surface area single oral dose every 6 wks.

Contra-Indications

Pregnancy, lactation, Hypersensitivity.

Special Precautions

Renal impairment. C.N.S disturbances, Monitor blood counts. Paediatrics: Not recommended in infants. Pregnancy : Safety not established. Lactation : Safety not established. Elderly : Use with caution.

Side Effects

Nausea, vomiting, seizures, Bone marrow depression is delayed for 6 wks. Visceral fibrosis and renal damage.

Drug Interactions

Theophylline cause leucopenia and thrombocytopenia.