Manifestations of psychotic disorders. Acute chronic paranoid schizophrenia.
Initial 10 mg twice daily. For severely disturbed : Initial upto 50 mg daily. Increase rapidly in 7-10 days. Usual therapeutic ose : 60-100 mg/day.
In comatose or severe drug induced depression states (alcohol, barbiturates, narcotics, etc.) in individuals with known hypersensitivity to benzodiazepines.
In patients with history of convulsive disorders. CVD, glaucoma, tendency to urinary retention. Paediatrics: Not recommended. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Use with caution.
Insomnia, dizziness, tardiv dyskinesia, tachycardia, neuroleptics malignant syndrome, hypotension, nausea/vomiting, headache, paresthesia, polydypsia.
Additive CNS depression with sedatives, hypnotics, antihistamines and opiates. Orthostatic hypotension with MAOIs. Anticholinergic effects potentiated by antiparkinson agents & tricyclic antidepressants. Antagonises antihypertensive effect of guanethidine, methyldopa and clonidine.