LYNESTRENOL

It is an oral preparation of the synthetic progestagen sharing various common activities with the natural hormone progesterone. It exerts a strong progestatinal influence on the endometrium. Lynestrenol suppresses ovulation and menstruation for as long as the preparation is taken daily without interruption.

Indications

Polymenorrhoea, menorrhagia & metrorrhagia, amenorrhoea & oligomenorrhoea. Premenstrual syndrome, endometriosis, endometrial carcinoma. Benign breast disease. Suppression of menstruation, ovulation and ovulation pain; dysmen-orrhoea. Postponement of menstruation. Endometrial hyperplasia.

Dosage

Polymenorrhoea : 5 mg daily on days 14-25. Menorrhagia : 10 mg daily for 10 days repeat for 3 cycles : 5 m on days 14-25. Endometriosis : 5-10 mg daily for 6 months. Dysmenorrhoea : 5 mg from 1-5th day for months. Postponement of menstruation : 5 mg daily 2 weeks prior to menstruation if 1 week before then 10-15 mg daily. Endometrial hyperplasia : 2.5-5 mg daily for 12-15 days per month.

Contra-Indications

Pregnancy or suspected pregnancy. Severe liver disease. Rotor syndrome & Dubin-Johnson syndrome. Undiagnosed vaginal bleeding, herpes gestationis, jaundice of pregnancy, otosclerosis, sever pruritis or porphyria.

Special Precautions

It may cause chloasma, changes in parameters of liver function, carbohydrate metabolism & haemostasis, acne & hirsutism, circulatory disorders, depression.

Side Effects

Breakthrough bleeding or spotting, change in libido, nausea, G.I. disturbances, weight increase. Headache, migraine, dizziness, nervousness, breast pain, oedema.

Drug Interactions

Failure of contraception with phenobarbitone, phenytoin, primidone, carba-mazepine, dichloralphenazone, rifampicin and broad spectrum antibiotics. Combination with ethinyloestradiol increases insulin requirement and reduced efficacy of oral anticoagulants.