Meropenem Trihydrate
It is a synthetic carbapenem Beta-Lactum antibiotic for parentral use. It has a potent bactericidal action against a broad spectrum of aerobic and anerobic bacteriaPneumonias, nosocomial pneumonias, intra-abdominal infections, gynecological infections, skin and skin structure infections, meningitis, septicaemia and adult febrile neutropenia
Administratered as a intravenous bolus injection over approximately 5 minutes or by intravenous infusion over approximately 15-30 minutes with compitable infusion (50-200ml) fluid. Adult : Pneumonias, UTI, gynaecological infections, skin and skin structure infections : 500mg 8hourly. Nosocomial Pneumonias, peritonitis, adult febrile neutropenia, septicamia: 1g every 8-hours. Meningitis : 2g every 8 hours. Children : Over 3 months and upto 12 years of age: 10-20mg/kg every 8 hours. Children ove
Hypersensitivity to ingredients. Hypersensitivity to penicillins or other beta-lactam antibiotics. Pseudomembranous colitis.Dosage should be reduced accordingly in patients with creatinine clearance less than 51ml/min. No dosage guideline is available in hemodialysis and peritoneal dialiasis. Monitor transaminase and bilirubin levels in patients with hepatic disease. Should not be mixed with or added to other drugs.
Paediatrics: Safety is not established in patient with neutropenia or primary/secondary immunodeficiency. Safety is not established in infants under 3 months of age. Pregnancy: Safety is not established. Lactation: Safety is not established. Elderly: Safe for elderly with normal renal functions.
Serious adverse effects are rare. Local IV injection site reaction, systemic allergic reaction, rash, pruritus, urticaria, abdominal pain, nausea, vomiting, diarrhoea, pseudomembranous colitis. Reversible thrombocythaemia, eosinophilia, thrombocytopenia, leucopenia and neutropenia. Headache, paresthesia, convulsions, oral and vaginal candidiasis.
Nephrotoxic drugs, probenocid, Sodium valproate.
