Meropenem with Tazobactam

Meropenem with Tazobactam is a combination antibiotic medication that contains meropenem, a carbapenem antibiotic, and tazobactam, a beta-lactamase inhibitor. This combination enhances the antibacterial spectrum of meropenem by inhibiting beta-lactamase enzymes, which are responsible for antibiotic resistance.

Indications

-Treatment of complicated intra-abdominal infections -Treatment of complicated skin and soft tissue infections -Management of complicated urinary tract infections -Pneumonia, including hospital-acquired and ventilator-associated pneumonia

Dosage

The dosage may vary based on the specific infection, patient's weight, and renal function. It is typically administered intravenously by a healthcare professional. Follow the prescribed dosage and duration as directed by the healthcare provider.

Contra-Indications

-Known hypersensitivity to meropenem, tazobactam, or any component of the formulation -Previous severe hypersensitivity reactions to other beta-lactam antibiotics

Special Precautions

-Caution in patients with a history of allergic reactions to beta-lactam antibiotics -Monitoring for signs of neurological adverse effects, especially in patients with CNS disorders -Use with caution in patients with impaired renal function; dosage adjustment may be necessary

Side Effects

Common side effects may include nausea, vomiting, diarrhea, headache, and injection site reactions. Serious side effects such as allergic reactions, seizures, or severe gastrointestinal issues should be reported to a healthcare professional promptly.

Drug Interactions

-Probenecid may increase the plasma concentration of meropenem -Concurrent use with valproic acid may increase the risk of seizures -Caution is advised when co-administered with drugs that may affect renal function