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It is a centrally acting skeletal muscle relaxant. Unlike neuromuscular blocking agents, it does not have direct effect on the contractile mechanism of striated muscle, the motor end plate or the never fiber.


Painful muscle spasm associated with musculoskeletal conditions.


Oral : Adult and children > 12 years = 800mg 3-4 times a day.


Hypersensitivity. Haemolytic or other anaemias. Significant impairment of renal or hepatic function.

Special Precautions

Pregnancy, Lactations Avoid alcohol, St John's wort and high-fat meal. Monitor Liver function tests. Do not drive or operate machinery. Elderly. Children under 12 years of age

Side Effects

Hypersensitivity reaction, headache, dizziness, nausea, vomiting, GI upset, rash, pruritus, nervousness, irritability, leucopenia, Hemolytic anemia, Jaundice. Metaxalone may cause false-positive Benedict's test.

Drug Interactions

Concurrent use of Alochol intake and CNS depressants may enhance sedative effects.

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