METHENAMINE

Methenamine is an antibacterial medication primarily used to prevent or control urinary tract infections (UTIs). It works by converting to formaldehyde in acidic urine, which then kills the bacteria causing the infection.

Indications

-Prophylaxis of recurrent urinary tract infections -Long-term prevention of UTI in patients with indwelling catheters

Dosage

-Adults: 1 g orally twice daily -Children (over 6 years): Dosage as directed by a physician -Elderly: Dose adjustment may be required based on kidney function

Contra-Indications

-Severe renal insufficiency -Severe hepatic insufficiency -Known hypersensitivity to methenamine or any component of the formulation

Special Precautions

-Monitor liver and kidney function periodically during prolonged therapy. -Ensure adequate fluid intake to maintain urine output. -Use with caution in patients with a history of liver disease.

Side Effects

-Nausea -Vomiting -Rash -Dysuria -Hematuria

Drug Interactions

-Avoid use with sulfonamides as they can form insoluble precipitates in urine. -Potential interaction with urinary alkalinizers which can reduce the efficacy of methenamine.