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METHENAMINE

METHENAMINE

METHENAMINE MANDELATE, a urinary antibacterial agent, is the chemical combination of mandelic acid with methenamine. p. Pathogens resistant to other antibacterial agents may respond to Mandelamine because of the nonspecific effect of formaldehyde formed in an acid urine.

Indications

Bacteriuria associated with pyelonephritis, cystitis, and other chronic urinary tract infections; also for infected residual urine sometimes accompanying neurologic diseases.


Dosage

Oral, 1m-4 g twice daily for adult and 0.25mg -1 g twice daily for 6-12 yr


Contra-Indications

renal insufficiency, hypersensitivity


Special Precautions

Dysuria may occur (usually at higher than recommended dosage). Patients with pre-existing hepatic insufficiency may suffer adverse effects from the small amounts of ammonia and formaldehyde that are produced. The classical syndrome of acute hepatic failure may be evoked in these patients. Paediatric: Use with caution Pregnancy: Category C; Use if risk to fetus outweighs benefits Lactation: Excreted in milk


Side Effects

An occasional patient may experience gastrointestinal disturbance or a generalized skin rash. Microscopic and rarely gross hematuria have been described.


Drug Interactions

Formaldehyde and sulfamethizole form an insoluble precipitate in acid urine; therefore, Mandelamine should not be administered concurrently with sulfamethizole.


Other Brands With Same Generic
Brand Name Manufactured by
MANDELAMINE PARKE-DAVIS INDIA LTD
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