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METHYL PREDNISOLONE SODIUM SUCCINATE

METHYL PREDNISOLONE SODIUM SUCCINATE

It has anti-inflammatory potency than hydrocortisone. It has a faster onset of action than Dexamethasone. It offers significant improvement in air-flow parameters like FVC & FEV1.It potentiates the action of Bronchodilators. Its use in emergency treatment of severe asthma can prevent significant morbidity. Methylprednisolone sodium succinate is a corticosteroid medication used to treat various conditions by reducing inflammation and suppressing the immune system. Methylprednisolone sodium succinate is a synthetic glucocorticoid, belonging to the corticosteroid class of drugs. It is available as a sterile white powder for intravenous or intramuscular administration after reconstitution.

Indications

-Inflammatory Conditions: Methylprednisolone sodium succinate is used to manage inflammation associated with various conditions, such as rheumatoid arthritis, osteoarthritis, and dermatologic disorders. -Allergic Reactions: It is prescribed for allergic and hypersensitivity reactions. -Respiratory Disorders: Treatment of severe asthma and chronic obstructive pulmonary disease (COPD). -Autoimmune Disorders: Used in autoimmune diseases like lupus and multiple sclerosis. -Organ Transplants: To prevent rejection after organ transplantation. -Severe Allergic Reactions: It can be administered in emergency situations for severe allergic reactions. -Allergic states, Respiratory diseases, Rheumatic disorders, Endocrine disorders, Collagen disease, Dermatologic diseases, Ophthalmic diseases, Haematologic disorders,Neoplastic disease, Oedematous states, Nervous system, Cardiovascular conditions, Organ Transplantation, Prevention of nausea and vomiting associated with cancer chemotherapy.


Dosage

-Dosage depends on the specific condition being treated, patient's age, weight, and overall health. It is usually administered as an injection under the supervision of a healthcare professional. -30mg per kg (IV) over a peroid of at least 30 min.,may be repeated every 4-6 hours up to 48 hours. Rheumatic disorders: 1 gm/day for 3-4 days(IV). Multiple sclerosis : 1 gm/day for 3 days(IV) or 1gm/day for 5 days(IV).


Contra-Indications

-Systemic Fungal Infections: Patients with systemic fungal infections should avoid methylprednisolone sodium succinate. -Hypersensitivity: Individuals with known hypersensitivity to corticosteroids should not use this medication. -Live Vaccines: Contraindicated in patients receiving live vaccines. -Systemic fungal infections. Known hypersensitivity to components.


Special Precautions

-Diabetes: Use with caution in patients with diabetes, as corticosteroids can elevate blood glucose levels. -Cardiovascular Disease: Caution is advised in individuals with a history of cardiovascular disease. -Infections: Increased susceptibility to infections; monitor for signs of infection during therapy. -Osteoporosis: Long-term use may lead to bone loss; consider calcium and vitamin D supplementation.


Side Effects

-Common side effects may include insomnia, increased appetite, weight gain, and fluid retention. Serious side effects include gastrointestinal bleeding, increased risk of infection, and adrenal suppression. -Aseptic necrosis of femoral and humeral heads, Peptic ulcer, Nausea, Vomiting and a bad taste in the mouth.


Drug Interactions

-Anticoagulants: Increased risk of bleeding with anticoagulant drugs. -Diuretics: Enhanced potassium loss with diuretic use. -Insulin and Oral Hypoglycemics: May require adjustment of diabetes medications. -Vaccines: Reduced efficacy of live vaccines; avoid live vaccines during treatment.


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