Methylprednisolone
Methylprednisolone is a corticosteroid medication used to suppress the immune system and decrease inflammation. It mimics the effects of hormones produced by the adrenal glands and is commonly used to treat a variety of conditions including allergic reactions, autoimmune diseases, and inflammatory conditions.-Allergic reactions (severe allergies, anaphylaxis) -Autoimmune diseases (rheumatoid arthritis, lupus) -Inflammatory conditions (asthma, chronic obstructive pulmonary disease, inflammatory bowel disease) -Endocrine disorders (adrenal insufficiency) -Skin conditions (eczema, psoriasis) -Neurological conditions (multiple sclerosis exacerbations) -Hematologic disorders (idiopathic thrombocytopenic purpura) -Certain cancers (leukemia, lymphoma)
The dosage of methylprednisolone varies widely based on the condition being treated, the severity of the condition, and patient response. It can be administered orally, intravenously, or intramuscularly. Typical oral dosages range from 4 mg to 48 mg per day, often in divided doses. Dosages for intravenous or intramuscular administration may be higher and are usually determined by a healthcare provider.
-Systemic fungal infections -Known hypersensitivity to methylprednisolone or any component of the formulation -Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses
-Use with caution in patients with a history of tuberculosis, peptic ulcer disease, osteoporosis, hypertension, and diabetes. -Long-term use can lead to adrenal suppression; gradual tapering of the dose is recommended to avoid withdrawal symptoms. -Monitoring is required for patients with electrolyte imbalances and in those who are pregnant or breastfeeding. -Avoid abrupt discontinuation after long-term therapy.
-Short-term: Insomnia, mood swings, increased appetite, fluid retention, and gastrointestinal discomfort. -Long-term: Osteoporosis, Cushing's syndrome, adrenal suppression, increased risk of infections, cataracts, and glaucoma. -Other possible side effects include hypertension, hyperglycemia, and muscle weakness.
-Increased risk of gastrointestinal bleeding with NSAIDs (e.g., ibuprofen, aspirin). -Enhanced hypokalemia with diuretics (e.g., furosemide). -Reduced effectiveness with antacids. -May interact with anticoagulants (e.g., warfarin), leading to altered effects. -Vaccines may have reduced effectiveness in patients on immunosuppressive doses.
