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METRONIDAZOLE

METRONIDAZOLE

It has been used for trichomoniasis, amoebiasis and giardiasis. Metronidazole is active against a wide range of bacteria including Bacteroides spp, anaerobic cocci, Fusobacterium spp, Clostridium spp. and Gardnerella, Vaginalis. It is also effective against protozoa including Trichomonas spp. Entamoeba histolytica and Giardialamblia.

Indications

Amoebiasis, giardiasis, trichomonas vaginitis, anaerobic infections (after colorectal or pelvic surgery, appendectomy, osteomyelitis and abscesses of brain or lung), ulcerative gingivitis.


Dosage

Orally 400 mg 8 hrly, by rectum 1 gm 8 hrly for 3 days followed by 1gm 12 hrly. i.v 500 mg 8 hrly. all upto 7 days.


Contra-Indications

Neurological disease, blood dyscrasias, first trimester of pregnancy.


Special Precautions

Lactation, disulfiram like intolerance to alcohol, phenobarbitones.


Side Effects

Anorexia, nausea, metallic taste, abdominal cramps, headache, glossitis, dryness of mouth, dizziness, peripheral neuropathy, CNS effects, seizures. Thromboflebitis of injected vein.


Drug Interactions

Disufiram-like reaction with alcohol. Enhances action of coumarin anticoagulants. Blood levels increased by cimetidine. Effect reduced by phenobarbitone. Acute psychoses with disulfiram. Additive/synergistic effect with other microbials.


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ARISTOGYL F ARISTO PHARMA
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ARISTOGYL PLUS ARISTO PHARMA
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CLEVO-M Corpus Lifescience Pvt. Ltd.
CLIZA-VL BENNET MYPHER PHARMA
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DEXOGYL AXA PARENTERALS LTD.
DIAFUZE AROMA LIFE SCIENCE
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DONNAGYL MISSION HAPPINESS DIVINE PVT LTD
DREZ-V STEDMAN PHARMACEUTICALS PVT. LTD.
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ENTEROFURAN-M DEYS MEDICAL STORES LTD.
ENTROFURAN-M DEYS MEDICAL STORES LTD.
FANTIM-M NEW GAYZEL PHARMAC-EUTICALS
FAST-AID DR. ETHIX's
FASTAID ETHIX HEALTHCARE
FINOFLOX-MZ CULMEN
FLAGYL-DF NICHOLAS PIRAMAL INDIA
FLAGYL-F NICHOLAS PIRAMAL INDIA
FLO-FLOX-M BINDLYSH BIOTEC LTD.
FUMEDIL JOHNSON AND JOHNSON
FUMEDIL JOHNSON AND JOHNSON
FUNGIN -V DRAKT INTERNATIONAL
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FYTOGYL BILLIARDS HEALTHCARE
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GYROFIX-M TOTAL HEALTHCARE PVT. LTD.
IDEFLOX-MZ IDEAL HEALTHCARE PVT. LTD.
IGCON STAR CREAM LIFECOM PRIMA (INDIA) PVT. LTD.
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LIFEGYL SUSP LIFECOM PRIMA (INDIA) PVT. LTD.
LOXNIX-MS TANSY MOLEQULE
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MEGYL-F INDOCO REMEDIES LTD.
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MERIDIN-M MERRIL PHARMA PVT. LTD
MET-D RAMPION LABORATORIES
METCLIN-CL SIGMAN WELLNESS
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METROGYL COMPOUND J.B. CHEMICALS AND PHARMACEUTICALS LTD
METROGYL DG J.B. CHEMICALS AND PHARMACEUTICALS LTD
METROGYL P J.B. CHEMICALS AND PHARMACEUTICALS LTD
METROGYL-F UNIQUE LIFE SCIENCES (P) LTD.
METROL ULTRA LABORATORIES PVT. LTD.
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MICOGENT KAPEETUS MEDICORP
MOFLO-0Z QUEST PHARMACEUTICALS
MYODIN-MS AXTER PHARMA
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NEOF-M ONEIRO PHARMACEUTICALS PVT. LTD.
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OFL-SEP-MS SAPHNIX MEDICURE
OFLASET M ZENOVA THERAPEUTICALS PVT. LTD.
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OFLET-M TYRANT PHARMA PVT. LTD.
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SUCRACEP-LM INCEPTA Division Of Aster Medipharm Pvt. Ltd
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TERBIZEST-M STARGEOMED
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