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MOXIFLOXACIN

MOXIFLOXACIN

The bactericidal action of moxifloxacin results from the interference with topoisomerase II and IV (DNA gyrase). Topoisomerases are essential enzymes that control DNA topology and assist in DNA replication, repair and transcription. It is effective against b-lactam and macrolide resistant bacteria.

Indications

Treatment of acute Bacterial Sinusitis Acute Bacterial Exacerbation of Chronic Bronchitis and Community Acquired Pneumonia in adult patients (18 years of age and above).


Dosage

-Oral/IV: Acute bacterial sinusitis: 400 mg once daily for 10 days Chronic bronchitis exacerbations: 400 mg once daily for 5 days Community-acquired pneumonia: 400 mg once daily for 7-14 days Skin infections: 400 mg once daily for 7-21 days, depending on severity Intra-abdominal infections: 400 mg once daily for 5-14 days Plague: 400 mg once daily for 10-14 days -Ophthalmic solution: Bacterial conjunctivitis: Instill 1 drop in the affected eye(s) 3 times daily for 7 days -400mg tablet taken orally every 24 hours.


Contra-Indications

-Hypersensitivity to moxifloxacin, other quinolones, or any component of the formulation -History of tendon disorders related to fluoroquinolone administration


Special Precautions

-Use with caution in patients with a history of tendon disorders or those at increased risk for tendon rupture (e.g., elderly, concurrent corticosteroid use). -Monitor for signs of tendonitis and tendon rupture; discontinue if symptoms occur. -Use with caution in patients with a history of seizures or other CNS disorders. -Prolongation of the QT interval; avoid in patients with known QT prolongation, uncorrected hypokalemia, or concurrent use of other QT-prolonging drugs. -Avoid excessive exposure to sunlight or UV light; use sunscreen and protective clothing. -Not recommended for use in pregnant or breastfeeding women due to potential risks.


Side Effects

-Nausea -Diarrhea -Headache -Dizziness -Tendonitis and tendon rupture -QT interval prolongation -Hypersensitivity reactions -Photosensitivity -CNS effects (e.g., seizures, confusion) -Hepatotoxicity


Drug Interactions

-Antacids, multivitamins, and other products containing magnesium, aluminum, iron, or zinc can interfere with absorption; take moxifloxacin at least 4 hours before or 8 hours after such products. -QT-prolonging drugs (e.g., amiodarone, sotalol, antipsychotics): Increased risk of QT prolongation and arrhythmias. -NSAIDs: Increased risk of CNS stimulation and seizures. -Antidiabetic drugs: Potential for hypoglycemia or hyperglycemia.


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