MUPIROCIN

It is a topical sterile antibiotic for the treatment of common bacteria skin infections. It is prepared by the fermentation of pseudomonas fluorescens. It inhibits in-vivo the synthesis of bacterical proteins by specific and reversible binding to isoleucyl transfer-RNA synthetase bacterical enzyme. Due to this particular mode of action, mupirocin does not show any cross-resistance with other antibiotics.

Indications

Primary skin infections: Impetigo, folliculitis, furunculosis and ecthyma. Secondary infections: Infected dermatosis e.g. infected traumatic lesions like abrasions, insect bites, minor wounds and minor burns. Prophylaxis: Mupirocin may be used to avoid bacterial contamination of small wounds, incisons and other clean lesions and to prevent infection of abrasions and small cuts and wounds.

Dosage

Three times a day for upto 10 days.

Contra-Indications

Hypersensitivity, not suitable for ophthalamic or intranasal use. Special Precautions: Avoid the eyes. Paediatrics: Use with caution. Pregnancy & Lactation: Avoid. Elderly: Safe.

Side Effects

Itching, burning, erythema, stinging and dryness localised to the area of application.

Drug Interactions

Mixing of mupirocin ointment with other preparaion may dilute mupirocin content and lead to reduction in antibacterial activity.