NACTIVATED RABIES VACCINE PREPARED ON VERO CELLS

N-activated rabies vaccine prepared on Vero cells is a modern, inactivated vaccine used for the prevention of rabies in humans. The vaccine is developed using Vero cells (a line of cells derived from the kidney of an African green monkey) as a substrate for cultivating the rabies virus. This process ensures a high degree of purity and effectiveness, and the vaccine is then inactivated, so it does not cause the disease.

Indications

The n-activated rabies vaccine is indicated for the following: Pre-exposure prophylaxis: For individuals at high risk of rabies exposure, such as veterinarians, animal handlers, travelers to high-risk areas, and laboratory workers dealing with rabies or related viruses. Post-exposure prophylaxis: For individuals who have been exposed to rabies, either through a bite, scratch, or other potential exposure to an infected animal.

Dosage

Pre-exposure: The standard schedule includes three doses (1 mL each) administered intramuscularly on days 0, 7, and 21 or 28. Post-exposure: For previously unvaccinated individuals, a regimen of four doses (1 mL each) is recommended on days 0, 3, 7, and 14. Additionally, rabies immune globulin should be given on day 0 at the same time as the first vaccine dose. Individuals who have been previously vaccinated should receive two doses (1 mL each) on days 0 and 3.

Contra-Indications

The vaccine is contraindicated in individuals with a history of severe allergic reactions to any of its components. People with severe illness should defer vaccination until they have recovered.

Special Precautions

Caution should be exercised when administering the vaccine to individuals with known allergies. Monitor individuals for signs of an allergic reaction after administration. Pregnant and lactating women should consult their healthcare provider before receiving the vaccine.

Side Effects

Common side effects include: Injection site reactions such as pain, redness, or swelling. Systemic reactions such as fever, headache, fatigue, or muscle aches. Rare but serious side effects can include: Severe allergic reactions (anaphylaxis). Neurological symptoms such as Guillain-Barré syndrome or transverse myelitis.

Drug Interactions

Immunosuppressive drugs may affect the vaccine's efficacy. Patients should inform their healthcare provider if they are taking any immunosuppressive medications. The vaccine should be given at a different site than other vaccines administered simultaneously.