Naproxen

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It works by inhibiting the production of prostaglandins, which are chemicals in the body that contribute to inflammation and pain.

Indications

Analgesic, antipyretic, dysmenorrhoea, rheumatoid arthritis, osteoarthritis, musculo-skeletal disorders, soft tissue injuries, tooth extraction, post-partum and post operatively, acute gout

Dosage

-Adults: Typically 250-500 mg twice daily. The maximum daily dose is 1000 mg. -Children: Dosage varies based on age and weight; consult a pediatrician for appropriate dosing.

Contra-Indications

-Allergy: History of allergic reactions to NSAIDs or aspirin. -Peptic ulcer: Active or history of peptic ulcer disease. -Severe kidney or liver disease. -Pregnancy: Particularly in the third trimester.

Special Precautions

Asthma, bleeding disorders, cardiovascular disease&those receiving coumarin anticoagulants.Aspirin/anti-inflammatory induced allergy.

Side Effects

-Common: Upset stomach, nausea, headache, dizziness, drowsiness. -Serious: Gastrointestinal bleeding, liver damage, kidney problems, severe allergic reactions, cardiovascular issues.

Drug Interactions

Aspirin displaces Ibuprofen from serum binding sites,reduces serum levels of flurbiprofen. Naproxen & Ketoprofen enhances effects of oral anticoagulants, phenytoin, methotrexate, sulphonamides, sulphonylurea hypoglycaemics & Probenecid increases their concentration