Nateglinide with Metformin

Nateglinide with Metformin is a combination medication used to manage blood sugar levels in individuals with type 2 diabetes. It combines two distinct antidiabetic agents, nateglinide and metformin, to enhance glycemic control through complementary mechanisms of action.

Indications

This combination is indicated for the treatment of type 2 diabetes mellitus in adults when diet and exercise alone do not provide adequate glycemic control.

Dosage

The dosage of Nateglinide with Metformin should be individualized based on the patient's response and tolerability. It is typically taken with meals to optimize its effectiveness. Consult with a healthcare professional for specific dosage recommendations.

Contra-Indications

This medication is contraindicated in individuals with a history of hypersensitivity to nateglinide, metformin, or any of the components in the formulation. It is also contraindicated in patients with severe renal impairment, hepatic insufficiency, or metabolic acidosis.

Special Precautions

-Caution is advised in patients with renal dysfunction, and renal function should be regularly monitored. -Liver function should be assessed periodically. -Discontinue treatment if lactic acidosis is suspected and seek medical attention. -Hypoglycemia may occur, especially in combination with other antidiabetic medications; monitor blood glucose levels closely.

Side Effects

Common side effects may include gastrointestinal symptoms (nausea, diarrhea, abdominal discomfort), hypoglycemia, headache, and dizziness. Report any unusual or severe side effects to a healthcare professional.

Drug Interactions

-Concomitant use with certain medications, such as beta-blockers, may affect glucose regulation. -Cationic drugs eliminated by renal tubular secretion may interact with metformin.