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NICLOSAMIDE

NICLOSAMIDE

Niclosamide is an anthelmintic medication used primarily to treat tapeworm infections in humans. It works by disrupting the parasite's ability to metabolize glucose, thereby eliminating the worm from the body. Highly effective drug against cestodes infesting man-Taenia Saginate, T. Solium, Diphyllobothrium latum and Hymenolepiasis nana. as well as thread worm. A saline purgative is given 2 hours after the dose to wash off the worm.

Indications

Treatment of intestinal tapeworm infections such as Taenia saginata (beef tapeworm) and Taenia solium (pork tapeworm)


Dosage

Adults and children over 6 yrs: 1gm followed by another dose of 1 gm one hour later. Single dose of 2 gm may also be given. Brisk purgative after 2 hours of last dose recommended. Children:(2-6yrs) 1 gm total dose in 2 divided doses.


Contra-Indications

-Hypersensitivity to Niclosamide or any of its components -Severe liver or kidney disease -Pregnancy, unless absolutely necessary and under medical supervision


Special Precautions

Digestion of the dead segments of injuredT. Solium can be hazardous, as the ova released from them may develop into larvae in the intestine, penetrate its wall and cause visceral cysticercosis, thus a thorough purge is essential: The scolex should be searched in the stools to be sure that the worm will not grow again. Paediatrics: Use with caution. Pregnancy: Use with caution. Lactation: Use with caution. Elderly: Safe.


Side Effects

-Gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal discomfort -Allergic reactions including rash and itching -Neurological symptoms in rare cases


Drug Interactions

-No significant drug interactions have been reported with Niclosamide -Inform your healthcare provider about all medications and supplements you are taking before starting Niclosamide


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