Nitazoxanide
It is a synthetic antiprotozoal drug; 2-acetyloxy-N-(5-nitro-2-thiazolyl) benzamide. Nitazoxanide exhibits antiprotozoal activity by interfering with PFOR (Pyruvate:ferredoxin oxidoreductase) enzyme dependent electron transport reaction that is essential for anaerobic energy metabolism.-Diarrhoea & Dysentery caused by Giardia lamblia & Cryptosporitidium parvum & Entamoeba histolytica. -Infections caused by Helminthes e.g. Trichuris trichiura, Ascaris lumbricoides, Hymenolepiasis nana & Enterobius vermicularis.
1-3 years : Nitazoxanide 100mg (5ml) BID for 3 days. 4-11 years : Nitazoxanide 200mg (10ml) BID for 3 days. 12 years & above : Nitazoxanide 500mg BID for 3 days. Pediatric dosage : 7.5mg/kg BID for 3 days.
-Hypersensitivity to nitazoxanide or any components of the formulation -Not recommended during pregnancy or breastfeeding unless prescribed by a healthcare provider
Nitazoxanide must be administered with caution in patients of hepatic, renal & biliary disease. Pregnancy: Category B.
-Common side effects include nausea, abdominal pain, headache, and dizziness -Rare but serious side effects may include allergic reactions and liver toxicity
No significant drug interactions have been reported; however, always inform healthcare providers about all medications being taken
| Brand Name | Manufactured by |
|---|---|
| NITACURE | ALEMBIC LTD. |
| NITCOL | Ranbaxy Laboratories Ltd. |
| NITOLEY | Zodley Pharmaceuticals Pvt. Ltd. |
| ZIMDAX | USV LTD. |
