Nitroglycerine
It is a volatile liquid which is absorbed on the inert matrix of tablet and rendered non explosive. The sublingual route is used when terminating an attack or aborting an imminent one. Nitroglycerine is readily absorbed from skin & a cutaneous application has effect for 4-6 hous. I.V. route provides rapid, steady titratable plasma concentration for as long as desired.Unstable angina, coronary vasospasm, LVF accompanying MI, hypertension during cardiac surgery.
Acute attack. 0.5 mg every 3 minutes till cessation of pain or limiting side effects appear. Prophylaxis : 0.5 mg prior to activity. To be chewed & not swallowed.
Cerebral haemorrhage, head trauma, hypertrophic cardiomyopathy.
cerebrovascular disease, lung disease. Paediatrics: Not usually prescribed. Pregnancy: Safety not established. Lactation: Caution.
Throbbing headache, flushing, weakness, sweating, palpitation, dizziness & fainting. Tachycardia. Methaemoglobinaemia.
Orthostatic hypotension may be produced by combined use of Calcium channel blockers, antihypertensives,phenothiazines & tricyclic antidepressants. Alcohol may cause severe hypotension & collapse.
