NORETHISTERONE

Norethisterone is a synthetic progestogen hormone commonly used in various gynecological conditions. It mimics the action of the natural hormone progesterone in the body, affecting the menstrual cycle and pregnancy. Norethisterone is often used to regulate menstrual cycles, treat menstrual disorders, and manage certain hormone-related conditions.

Indications

Norethisterone is indicated for the treatment of several conditions, including: Irregular menstrual cycles Heavy menstrual bleeding (menorrhagia) Endometriosis Premenstrual syndrome (PMS) Contraception (in specific formulations) Delaying menstruation for convenience Hormone replacement therapy (HRT)

Dosage

For irregular or heavy periods: 5 to 10 mg taken daily for a specified period, usually from the 5th to 25th day of the menstrual cycle.

Contra-Indications

Norethisterone should not be used in individuals with: Known or suspected pregnancy History of thromboembolic disorders (blood clots) Active liver disease or impaired liver function Hormone-sensitive cancers (e.g., breast cancer) Undiagnosed vaginal bleeding Severe cardiovascular disease

Special Precautions

Monitor for signs of thromboembolism (e.g., deep vein thrombosis, pulmonary embolism) Use with caution in patients with a history of depression or liver disease.

Side Effects

Nausea and vomiting Headache Dizziness Breast tenderness Weight changes Mood swings Changes in menstrual flow or timing Acne

Drug Interactions

Norethisterone may interact with other medications, including: Enzyme-inducing drugs (e.g., rifampicin, phenytoin) that may reduce its effectiveness. Anticoagulants, which could affect blood clotting. Other hormonal therapies, which may cause unwanted side effects.