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NORTRIPTYLINE

NORTRIPTYLINE

Tricyclic antidepressants inhibit the active uptake of biogenic amines NA, 5 HT and DA into their respectiveurones. Nortriptyline is non selective for different amines but has more effect on NA than on 5-HT uptake.

Indications

Manic depressive psychosis in the depressive phase. Neurotic, endogenous, reactive, involutional or masked depression.


Dosage

Adults: 50-150 mg/day. Children: 8-11 yrs: 10-20 mg/day. >11 Yr: 25-35 mg/day. The dose should be given at the bed time with food.


Contra-Indications

Narrow angle glaucoma. Urinary retention (specially in males with enlarged prostate. Acute myocardial infarction.)


Special Precautions

Treatment should not continue for longer than 3 months. Cardiovascular disease. Renal & hepatic impairment. Epilepsy, Diabetes, Hyperthyroidism, hypomania or mania. Paediatrics: Reduce the dose. Pregnancy & Lactation: Contraindicated. Elderly: Reduced dose necessary.


Side Effects

Sedation & mental confusion, dry mouth, constipation, epigastric distress. Cardiac arrhythmias, jaundice, rash, tremors, altered vision.


Drug Interactions

Potentiates hypertensive effect of nordrenaline and anticoagulant action of coumarins, severe hyperpyretic reaction with MAOIs, hence should not be used within 2 weeks of stopping MAOIs.Cimetidine increases the plasma concentration.


Other Combination Brands
Brand Name Manufactured by
AGABA-N ATRAL CYRUS LIFESCIENCES
ALNEX-NT ALEMBIC LTD.
APOLAR-NT LIFECARE NEURO PRODUCT LTD.
AXOGURD NT ALEMBIC LTD.
COBAZADE-NT DAIKON PHARMACEUTICALS PVT LTD
COBISET-NT AIOMAX MEDICO
CROMIN-NR CROISE PHARMA PVT. LTD.
DUBINOR GLENMARK PHARMA
ENPM VOWCARE PRODUCTS
GABADON-NT BONDANE PHARMA
GABAGE-N ALLENGE INDIA
GABAGET-NT GNF ETHICALS
GABAJOINT N GOODMAN GILMAN'S LIFESCIENCES PVT.LTD
GABALIV-N ASTEMAX BIOTECH
GABALOX NT VELOX BIOLOGICS PVT. LTD
GABAMAX NT ARISTO PHARMA
GABANEURON NT ARISTO PHARMA
GABASOL NT ANT PHARMACEUTICALS PRIVATE LIMITED
GABIMAX-N JOHNLEE PHARMACEUTICALS
GABLIS-NT ZORION DRUGS & HERBS PVT.LTD
GABTY-P SPANSA PHARMACEUTICALS PVT LTD
GEOCOOL-NT STARGEOMED
GORNAT MEDICS LIFECARE
KAIZYT KUMAD PHARMA
KAIZYT-100 KUMAD PHARMA
LYCOMERVE-NT CENTURY LIFE SCIENCE PVT. LTD.
MAXIMINE TOTAL CANSAS LIFECARE
MECOBOON-P MEDIBOON PHARMA PVT. LTD
MEGANEURON-NT ARISTO PHARMA
MG-NOR MEDICS LIFECARE
MOSAMIN-NT MAUSDI PHARMA
NERVILIN-NM Zodley Pharmaceuticals Pvt. Ltd.
NERVILIN-NT Zodley Pharmaceuticals Pvt. Ltd.
NERVIZ-PG BIO CLARIS DRUGS
NERVLEX-NT ZORION DRUGS & HERBS PVT.LTD
NEUROCOB-PN LEZAA BIOTECH
NEURODIN TOTAL DIVINE SAVIOR
NEURODIN-NT DIVINE SAVIOR
NEUROLIFE-NT VOWCARE PRODUCTS
NIKWEL-FORTE MARTYN NIKK PHARMA PRIVATE LIMITED
NOR-PM ORMED HEALTHCARE PVT. LTD.
NORGPTIN CENTURIAN LABORATORIES
NORTIPIN PINARC LIFE SCIENCES
NORTRYPTOMER-P WOCKHARDT LTD.
NT-GABA SALVO DRUGS PVT. LTD.
NUROMAX-NT ACTIVE HEALTH CARE
NUROSAM-NT SAMSON LABORATORIES PVT. LTD.
ORNAAVOLT-NT RAVENMAC PHARMA PVT.LTD
ORNAVOLT-3D RAVENMAC PHARMA PVT.LTD
PRE-MNT EUNIKA THERAPEUTICS PVT LTD
PREBEL-N JOHNLEE PHARMACEUTICALS
PREGABID NT INTAS PHARMACEUTICALS LTD.
PREGALIFT NT LINUX LAB
PREGALIFT PLUS LINUX LAB
PREGALIN NT TORRENT PHARMACEUTICALS
PREGARISH NT CUREISH HEALTHCARE
PREGASOFT-N ASTEMAX BIOTECH
PREGASOL-NT ANT PHARMACEUTICALS PRIVATE LIMITED
PREGAT-NT ATOZ
PREGAVIS-NT VISION BIOLIFE PVT.LTD
PREGMORE-NT NYSON REMEDIES
PREGZARA-M ZYRA ORGANIC
PRENOR-NT ANGIA RX DRUG FORMULATION
PRENU-NM TRAUMAFINE PHARMACEUTICALS
PRIMAC-NT WELGENIC PHARMA
PROAGE-NM ALLENGE INDIA
REJUNIK-NT JAINIK LIFE SCIENCES
RIGALIN-NT HOCHEST BIOTECH
SENSIVAL-P WALLACE PHARMACEUTICALS LTD
SERTIVA EMCURE PHARMA
THYGABA-PLUS FOREX PHARMACEUTICAL
WEGAB-NT WELGENIC PHARMA
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