NORTRIPTYLINE WITH PREGABALIN
Nortriptyline is a tricyclic antidepressant (TCA), while pregabalin is an anticonvulsant medication. When used together, they may complement each other's effects in managing certain conditions.-Chronic neuropathic pain -Fibromyalgia -Generalized anxiety disorder (off-label use) -Depression with comorbid anxiety
Dosage may vary depending on the individual's condition, medical history, and response to treatment. It's crucial to follow the prescribing physician's instructions carefully.
-Hypersensitivity to nortriptyline, pregabalin, or any components of the formulations -Recent myocardial infarction -Concomitant use of monoamine oxidase inhibitors (MAOIs) -Acute recovery phase following myocardial infarction
-Close monitoring for worsening of depression or emergence of suicidal thoughts, especially at the beginning of treatment or with dose adjustments. -Caution in patients with a history of cardiac disease, seizures, urinary retention, or glaucoma. -Use with caution in the elderly population due to increased risk of falls, cognitive impairment, and cardiac conduction abnormalities. -Avoid abrupt discontinuation of either medication to minimize withdrawal symptoms. -Monitor for signs of serotonin syndrome if used concurrently with other serotonergic agents.
Side effects can vary between individuals and may include: -Nortriptyline: dry mouth, constipation, blurred vision, urinary retention, sedation, weight gain, cardiac arrhythmias. -Pregabalin: dizziness, somnolence, peripheral edema, weight gain, blurred vision, dry mouth, constipation.
-MAOIs: Increased risk of serotonin syndrome. -Serotonergic agents (e.g., SSRIs, SNRIs): Increased risk of serotonin syndrome. -CNS depressants: Enhanced sedative effects. -Anticholinergic agents: Additive anticholinergic effects. -CYP450 inhibitors/inducers: Potential for altered metabolism of nortriptyline. -Alcohol: Increased risk of CNS depression and impairment.
