Menopausal syndrome, senile vaginitis, delayed puberty in gils. Postmenopausal osteo- porosis. Contraceptive. Dysmenorrhoea. Acne, hirsutism. Functional uterine bleeding. Suppresion of lactation. Carcinoma prostate, carcinoma breast.
Pregnancy, lactation, undiagnosed vaginal bleeding. Cardiovascular or cerebrovascular disorders e.g. thrombophlebitis, thrombo-embolic processes. Severe hepatic impairment. Hypertension. Herpes gestationis. Rotor syndrome,Dubin-Johnson syndrome.Porphyria. Endometrial hyperplasia. Hyperlipoproteinaemia. Suspected estrogen dependent neoplasia tumours.
Epilepsy, migraine, asthma, cardiac or renal disease. Discontinue if cancer progression or hypercalcaemia occur. May cause salt & fluid retention, chronic mastitis, abnormal mammograms. Impending major surgery.
Suppression of libido, gynaecomastia & feminization in males.Endometrial carcinoma.Breast cancer. Benign hepatomas. Fusion of epiphyses & reduction of adult stature when given to children.
Rifampicin, barbiturates and phenytoin increase rate of metabolism. Enhance toxic effects of imipramine reduce effectiveness of anticoagulants and enhance activity of phenytoin.