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Orlistat is a reversible inhibitor of lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. The inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides. As undigested triglycerides are not absorbed, the resulting caloric deficit may have a positive effect on weight control.


Obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. To reduce the risk for weight regain after prior weight loss.


Orlistat 120mg three times a day given along with meal as an adjuvant to diet and exercise.


Chronic malabsorption syndrome or cholestasis, hypersensitivity.

Special Precautions

Patients should be advised to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because orlistat has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene. Warnings: Organic causes of obesity (e.g., hypothyroidism) should be excluded.

Side Effects

Oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation, fecal incontinence. Pregnancy:- Teratogenic effect & Pregnancy category B, Nursing Mothers, Pediatric Use, Geriatric Use.

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