PIROXICAM

Its anti-inflammatory potency is similar to indomethacin and analgesic action is greater than aspirin. It has useful antipyretic property.

Indications

Rheumatoid arthritis, osteoarthritis, ankylosing Spondylitis. Acute musculo-skeletal disorders. Acute gout.

Dosage

Rheumatoid arthritis, osteoarthritis, ankylosing, Spondylitis: 20 mg daily as single dose. Maint. 10-30 mg. Acute Musculo-skeletal disorders: 40 mg in a single or divided doses for 7-14 days. Acute gout : 40 mg as a single dose. Maint : 40 mg in single or divided doses for 4-6 days.

Contra-Indications

Hypersensitivity, Pregnancy, children patients who develop asthma or allergy with other inflammatory drugs, lactation.

Special Precautions

Renal or hepatic dysfunction, asthma, surgery, haemorrhagic disorders. Hypertension, cardiovascular disease. Paediatrics: Not recommended in age below 6 yrs. Pregnancy:Contraindicated,may affect the foetus Lactation: Safety not established. Elderly: Reduced dose necessary

Side Effects

Heart burn, nausea, anorexia, rashes, pruritus, C.N.S. manifestations. Oedema

Drug Interactions

Potentiate anticoagulants. Diuretics increase risk of renal damage. Monitor lithium levels. Aspirin reduces serum levels